Curriculum Vitae
Jinghua Wang, Ph.D.

Education
Research and Professional Experience
Honors and Academic Awards
Research Support
Memberships
Teaching Experience
Publications

EDUCATION

1997, Ph.D.
Jilin University - Immunology
Norman Bethune Medical Science Center
Changchun, China

1991, M.Sc.
Medical school of Jiamusi University - Immunology
Jiamusi, China

1985, B.Sc, - Biology
Harbin Normal University
Harbin, China  

Post Doctoral Training

1997-1999
Peking University Health Science Center, Beijing, China

1999-2003
Department of Pharmacology
University of Minnesota, Minneapolis

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RESEARCH AND PROFESSIONAL EXPERIENCE:

Oct. 2007- Present
Research Assistant Professor, Department of Surgery
University of Minnesota, Minneapolis

July 2007-Sept. 2007
Research Associate, Department of Pharmacology
University of  Minnesota, Minneapolis

March 2005- July 2007
NRSA trainee, Veterinary Population Medicine
University of Minnesota, Minneapolis

Apr. 2003 - Mar. 2005
Research Associate, Department of Pharmacology
University of  Minnesota, Minneapolis

Aug. 1999 - Apr. 2003
Postdoctoral, Department of Pharmacology
University of  Minnesota, Minneapolis

Sept.1997 - Aug. 1999
Postdoctoral, Department of Physiology
Peking University Health Science Center, China

Sept. 1994 - Sept. 1997
Research Assistant, Department of Immunology
Jilin University Norman Bethune Medical Science Center, China

July 1985 - July 1994
Assistant Instructor & Instructor, Department of Microbiology and Immunology, Jiamusi University, China

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HONORS AND ACADEMIC AWARDS:

Postdoctoral Fellowship (1997-1999)
– from China Postdoctoral Council for training at Peking University Health Science Center.

Young Investigator Travel Award (2001)
- from Society on Neuroimmune Pharmacology to attend and present research findings at ‘8th Conference Neuroimmune Circuits & Infectious Disease’
March 2001-Emory University, Atlanta, Georgia.

Young Investigator Travel Award (2002)
- from Society on Neuroimmune Pharmacology to participate and present research findings at ‘9th Conference Neuroimmune Circuits & Infectious Disease’
October 3-6, 2002-Clearwater, Florida.

Postdoctoral traineeship (2005-2007)
NIDA training grant in Neuro-behavior/ Neuro-immune Addiction Research (NIH DA07097-24; PI Thomas Molitor)

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RESEARCH SUPPORT:

09/25/2007-10/31/2009
NIH/NIDA, R03 DA023353-01A2 (Jinghua Wang - PI)
Opioid abuse and host defense against S. pneumoniae lung infection

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MEMBERSHIPS:

American Society on Neuro-immune Pharmacology (2002-)
Chinese Immunology Society (1994-1999)

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TEACHING EXPERIENCE:

Undergraduate Courses
Medical school of Jiamusi University, China

Immunology (1988-1994) 

Graduate Courses
Norman Bethune Medical Center of Jilin University, China

Immunology (1994-1997)

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PUBLICATIONS:

1. Wang J, Roderick A. Barke, Richard Charboneau, Reto Schwendener, Sabita Roy. (2008) Morphine induces defeats in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kB signaling. Revised to Journal of Immunology.

2. Wang J, Barke RA, Roy S.  (2007) Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. J Biol Chem. 282(10):7164-71.

3. Roy S, Wang J, Kelschenbach J, Koodie L, Josephine Martin J. (2006) Modulation of Immune Function by Morphine: Implications for Susceptibility to Infection. Journal of Neuroimmunopharmacology.1 (1):77.

4. Roy S, Wang J, Charboneau R, Loh HH, Barke RA. (2005) Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway. J Immunol. 175(10):6361-6367.

5. Wang J, Barke RA, Charboneau R, Roy S. (2005) Morphine impaires host innate immune response and increases susceptibility to pneumococcal lung infection. J. Immunol. 174(1):426-34.

6. Roy S, Wang J, Gupta S, Charboneau R, Loh HH, Barke RA. (2004) Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J. Neuroimmunol. 147(1-2):78-81.

7. Roy S, Balasubramanian S, Wang J, Chandrashekhar Y, Charboneau R, Barke R. (2003) Morphine inhibits VEGF expression in myocardial ischemia. Surgery. 134(2):336-44.

8. Wang J, Barke RA, Charboneau R, Loh HH, Roy S. (2003) Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways. J Biol Chem. 278(39):37622-31

9. Wang J., R. Charboneau, R. A. Barke, H. H. Loh, and S. Roy. (2002) Mu-opioid receptor mediates chronic restraint stress induced lymphocytes apoptosis. J. Immunol.169 (7):3630-3636.

10. Wang J., R. Charboneau, S. Balasubramanian, R. A. Barke, H. H. Loh, and S. Roy. (2002) The immunosuppressive effects of chronic morphine treatment is partially dependent on corticosterone and mediated by the -opioid receptor. J. Leukocyte Biol. 71(5); 782-790.

11. Roy S, Balasubramanian S, Sumandeep S, Charboneau R, Wang J, Melnyk D, Beilman GJ, Vatassery R, Barke RA. (2001) Morphine directs T cells toward T(H2) differentiation. Surgery. 130(2):304-309

12. Roy S, Wang J, Balasubramanian S, Sumandeep, Charboneau R, Barke R, Loh HH (2001). Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout mice. J Neuroimmunol 116(2):147-155

13. Balasubramanian. S. Sundaram, R, Charboneau R, Wang J., Barke R. A., Loh H. H., and Roy S. (2001) Morphine Sulfate Inhibits Hypoxia-induced vascular endothelial growth factor expression in endothelial cells and cardiac myocytes  J. Molecular & Cellular Cardiology. 33(12); 2179-2187

14. Wang J., R. Charboneau, S. Balasubramanian, R. A. Barke, H. H. Loh, and S. Roy. (2001) Morphine modulates lymph node-derived T lymphocyte function: role of caspase-3, -8, and nitric oxide. J. Leukocyte Biol. 70(4); 527-536

15. Roy S, Balasubramanian S, Sumandeep S, Charboneau R, Wang J, Melnyk D, Beilman GJ, Vatassery R, Barke RA. (2001) Morphine directs T cells toward T(H2) differentiation. Surgery. 130(2):304-309

16. Wang J, Sun Z, Yang G. (1997) Nitric oxide and autoimmune disease. Foreign Medical Sciences Section of Pathophysiology and Clinical Medicine. 17(1): 58-60

17. Wang J, Zheng Y, Yang G. (1997) The effect of intrahippocampal nitric oxide on cellular immune function via hippocampus-neuropeptide Y-pituitary-adrenal axis in septo-hippocampal lesion rat Chinese Journal of immunology .14(1);37-39

18. Wang J, Yang G. (1997) The effect of intrahippocampal nitric oxide on learning ability via NO-cGMP-Glu-[Ca2+]i pathway in rat. Chinese Journal of Neuroimmunology and Neurology.4(4);212-215

19. Wang J, Yang G. (1997) Influence of nitric oxide on learning in rats. Chinese Journal of Neuroimmunology and Neurology.4(1);11-13

20. Wang J Yang G, Yang S. (1997) Determination of nitric oxide level in tissue and serum by fluorespectrophtometry. Chinese Progress of Biochemistry and Biophysics.  24(4);363-366

21. Wang J Yang G, Yang S. (1997) Determination of nitric oxide level in tissue and serum by fluorespectrophtometry. Chinese Progress of Biochemistry and Biophysics.  24(4);363-366

22. Wang J, Yang G. (1996) Autoreactive T cells and autoimmune disease. Foreign Medical Sciences Section of Immunology. 3; 120-123

23. Wang J, Yang G. (1996) T and B memory cell. Chinese Immunological Journal.  24(4);273-275.

24. Jin Z, Wang J, Li S et al. (1996) The change of plasma nitric oxide level in normal pregnant and pregnancy induced hypertension. Chinese Journal of Obstetrics and Gynecology. 31;594-596.

25. Wang J, Yang G, Yang S et al. (1996) Determination of nitric oxide of brain by fluorescence  spectroscopy. Chinese Journal of Luminescence. 17(4): 369-371

26. Wang J, Yin J, Bai X et al. (1994) 91 mixture accelerates recovery of immune function fellow sublethal irradiation. Chinese Journal of radiation medicine and protection. 14;86-89

27. Bai F, Chen Z, Wang J et al. (1993) Experimental study for effect of Zn and Cu on immune  function and antisenility in elderly rats. Chinese Journal of Microbiology and Immunology. 13(2);80-84

28. Li S, Lu X, Wang J et al. (1992) Effect of c-myc mRNA transcription change on cell malignant transformation. Chinese Journal of Heredity. 14(1);16-18

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