Research Projects

The Surgery Clinical Trials Office (SurgCTO) supports the research activities for the Surgery Division clinical faculty at the University of Minnesota. SurgCTO is currently conducting approximately 45 clinical trials in various phases of enrollment and follow-up with a mix of investigator-initiated, industry sponsored and government-sponsored trails.

There are active clinical research trials in the following divisions:

We also provide support for Humanitarian Use Devices (HUDs).

Bariatric

Bariatric

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • ADA - Bariatric Surgery and Adipose Inflammation Dysfunction and Type 2 Diabetes Mellitus
  • CHAAMPS - Bariatric Surgery in African American Males
  • ReCharge PAS - The Safety and Efficacy of vBloc Therapy Delivered by the Maestro Rechargeable System for the Treatment of Obesity

Cardiothoracic

Cardiothoracic

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463

  • BAL Pilot Study - Pilot study for Tracking Graft Antigen-Specific CD4+ T-cells in Lung Transplant Recipients
  • EXPAND Lung II - Trial to Evaluate the Safety and Effectiveness of The Portable Organ System (OCS™) Lung System for Recruiting, Preserving and Assessing Non-Ideal Donor Lungs for Transplantation
  • Human Valve Tissue - Pilot Study for Collecting Human Cardiac Valve Specimens in Autoimmune Cardiac Valve Inflammation
  • Intermacs - Interagency Registry for Mechanically Assisted Circulatory Support
  • MOMENTUM CAP - Study of MagLev Technology in Patients Undergoing MCS Therapy With HeartMate 3™ Continued Access Protocol
  • NuPulse - Feasibility Study of the Intravascular Ventricular Assist System (iVAS)
  • Pedimacs - Pedimacs is the pediatric portion of Intermacs
  • SUSTAIN-IT - Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support
  • TOP Registry - The Organ Care System (OCS) Lung Thoracic Organ Perfusion (TOP) Post Approval Study (PAS) Registry

Solid Organ Transplant

Solid Organ Transplant

  • Decision Aid
  • Donor Long-Term Follow Up
  • Patient Center Report Card

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • ASTOUND - To Compare the Effects of Immediate-Release Tacrolimus and Astagraf XL on Donor-Specific Antibody Formation and the Development of Immune Activation in de Novo Kidney Transplant Recipients
  • BB3A Multicenter, Prospective, Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study of BB3 to Reduce the Severity of Delayed Graft Function in Recipients of a Deceased Donor Kidney
  • CSL Behring - Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as an add-on to Standard of Care for the Treatment of Refractory Antibody-Mediated Rejection (AMR) in Adult Renal Transplant Recipients
  • CONNEKT (Shire AMR) -  Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-Mediated Rejection in Patients with Kidney Transplant
  • DeKAF - A Study of Factors That Affect Long-Term Kidney Transplant Function
  • Envarsus Rapid Metabolizers - An Observational Study to Determine If Early Tacrolimus Troughs Detect Rapid Tacrolimus Metabolizers
  • Envarsus - Comparison of the Cognitive and Motor Effects of Treatment Between and Immediate and Extended Release Tacrolimus Based Immunosuppression Regimen in Kidney Transplant Recipients
  • ENLIST - Evaluating Nulojix (Belatacept) Long-Term Safety in Transplant
  • HOPE Act - Observational Study of Solid Organ Transplantation Utilizing HIV-Positive Donors in HIV-Positive Recipients
  • KOAR - Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry
  • Liver PROTECT - TransMedics (OCS) Liver Trial: Preserving and Assessing Donor Livers for Transplantation
  • Lost WagesEffect of Lost Wage Reimbursement to Potential Kidney Donors On Living Donation Rates 
  • SCCa - Underlying Molecular Mechanisms in Development of Skin Squamous Cell Carcinoma in Transplant Recipients and General Population
  • ValA vs ValG - ValGanciclovir Versus ValAcyclovir for Viral Prophylaxis in Kidney Transplantation

Vascular

Vascular

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • Valiant Evo - Valiant Evo US Clinical Trial
  • Low Dose - Development of Ultra-Low Dose CT Based Screening for Aortic Aneurysms
  • RelayPro - Study of the RelayPro Thoracic Stent-Graft in Subjects with an Acute, Complicated Type B Aortic Dissection

Humanitarian Use Device (HUD)

Humanitarian Use Device (HUD)

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • Enterra - HDE (Human Device Exemption) Enterra Therapy Gastric Stimulation
    Open to Enrollment

Gastroenterology

Gastroenterology

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • Right Colectomy - A Multi-Center Prospective Comparison of Intracorporeal and Extracorporeal Anastomoses for Minimally Invasive Right Colectomy