Research Projects

The Surgery Clinical Trials Office (SurgCTO) supports the research activities for the Surgery Division clinical faculty at the University of Minnesota. SurgCTO is currently conducting approximately 45 clinical trials in various phases of enrollment and follow-up with a mix of investigator initiated, industry sponsored and government sponsored trails.

There are active clinical research trials in the following divisions:

  • Bariatric
  • Cardiothoracic
  • Solid Organ Transplant
  • Vascular

We also provide support for Humanitarian Use Devices (HUDs).

Bariatric

Bariatric

  • Factors Impacting Healthcare Utilization
  • Paraesophageal Hernia Repair

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • ADA - Bariatric Surgery and Adipose Inflammation Dysfunction and Type 2 Diabetes Mellitus
  • ReCharge PAS - The Safety and Efficacy of vBloc Therapy Delivered by the Maestro Rechargeable System for the Treatment of Obesity

Cardiothoracic

Cardiothoracic

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • EXPAND Lung - International Trial to Evaluate the Safety and Effectiveness of The Portable Organ Care System (OCS™) Lung For Recruiting, Preserving and Assessing Expanded Criteria Donor Lungs for Transplantation
  • EXPAND Lung II - Trial to Evaluate the Safety and Effectiveness of The Portable Organ System (OCS™) Lung System for Recruiting, Preserving and Assessing Non-Ideal Donor Lungs for Transplantation
  • Intermacs - Interagency Registry for Mechanically Assisted Circulatory Support
  • MOMENTUM CAP - Study of MagLev Technology in Patients Undergoing MCS Therapy With HeartMate 3™ Continued Access Protocol
  • Pedimacs - Pedimacs is the pediatric portion of Intermacs
  • SUSTAIN-IT - Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support

Solid Organ Transplant

Solid Organ Transplant

  • Decision Aid
  • Donor Long-Term Follow Up
  • Microbiome in Kidney Transplantation
  • Patient Center Report Card

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • ASTOUND - To Compare the Effects of Immediate-Release Tacrolimus and Astagraf XL on Donor-Specific Antibody Formation and the Development of Immune Activation in de Novo Kidney Transplant Recipients
  • BEST - Belatacept Early Steroid Withdrawal Trial
  • CSL Behring - Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as an add-on to Standard of Care for the Treatment of Refractory Antibody-Mediated Rejection (AMR) in Adult Renal Transplant Recipients
  • CONNEKT (Shire AMR) -  Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-Mediated Rejection in Patients with Kidney Transplant
  • DART - Non-Invasive Blood Test To Diagnose Acute Rejection After Kidney Transplantation
  • DeKAF - A Study of Factors That Affect Long-Term Kidney Transplant Function
  • Envarsus - Comparison of the Cognitive and Motor Effects of Treatment Between and Immediate and Extended Release Tacrolimus Based Immunosuppression Regimen in Kidney Transplant Recipients
  • ENLIST - Evaluating Nulojix (Belatacept) Long-Term Safety in Transplant
  • HOPE Act - Observational Study of Solid Organ Transplantation Utilizing HIV-Positive Donors in HIV-Positive Recipients
  • KOAR - Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry
  • Liver PROTECT - TransMedics (OCS) Liver Trial: Preserving and Assessing Donor Livers for Transplantation
  • Lost WagesEffect of Lost Wage Reimbursement to Potential Kidney Donors On Living Donation Rates 
  • SCCa - Underlying Molecular Mechanisms in Development of Skin Squamous Cell Carcinoma in Transplant Recipients and General Population
  • Shire AMR QoL - An Observational, Cross-Sectional Study to Assess the Quality of Life (QoL) of Kidney Transplant Patients with Acute Antibody-Mediated Rejection (AMR)
  • ValA vs ValG - ValGanciclovir Versus ValAcyclovir for Viral Prophylaxis in Kidney Transplantation

Vascular

Vascular

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • Valiant Evo - Valiant Evo US Clinical Trial
  • Low Dose - Development of Ultra-Low Dose CT Based Screening for Aortic Aneurysms
  • RelayPro - Study of the RelayPro Thoracic Stent-Graft in Subjects with an Acute, Complicated Type B Aortic Dissection

Humanitarian Use Device (HUD)

Humanitarian Use Device (HUD)

For additional information about the below trial(s) please contact surgcto@umn.edu or 612-624-7463.

  • Enterra - HDE (Human Device Exemption) Enterra Therapy Gastric Stimulation
    Open to Enrollment